platelet refractoriness the basics
The Basics of Platelet Transfusion
• Confirm refractoriness on the basis of at least 2 post-transfusion count increments • Consider patient factors rule out/consider non-alloimmune causes of platelet refractoriness • Consider platelet factors • Older platelet concentrate age (>48 hrs) and ABO platelet incompatibility is associated with worse
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ISBT Platelet Immunobiology
Platelet disorders caused by antibodies against platelets include immune thrombocytopenia fetal/neonatal alloimmune thrombocytopenia drug-induced immune thrombocytopenia and platelet-transfusion refractoriness. Rapid and precise diagnosis using reliable platelet serology testing is mandatory to avoid severe clinical consequences for patients.
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Idiopathic Thrombocytopenic Purpura Johns Hopkins Medicine
Idiopathic thrombocytopenic purpura is a blood disorder characterized by an abnormal decrease in the number of platelets in the blood. A decrease in platelets can result in easy bruising bleeding gums and internal bleeding. ITP may be acute and resolve in less than 6
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Management of Patients Refractory to Platelet Transfusion
Options for managing platelet refractoriness caused by alloimmunization include platelet transfusion from human leukocyte antigen–matched or donor-recipient cross-matched platelets.
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Platelet refractoriness Request PDF
Platelet refractoriness (unsatisfactory post-transfusion platelet increment) is a severe problem that impairs the treatment of oncohematologic patients and is not routinely investigated in most
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PPT Basics of Transfusion TherapyMichigan Medicine
Platelet Refractoriness Laura Cooling MD MS Associate Medical Director Transfusion Medicine Platelet Kinetics circulating life span 8-10 days Definitions of Refractoriness 2-3 consecutive platelet transfusions by CCI or PPR REFRACTORINESS ALLOIMMUNIZATION Platelet Refractoriness Immune (25-50 ) Alloimmunization Autoantibodies Passive Immunity Drug-related Nonimmune (50
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Understanding the Impact of Platelet ABO MatchingPart 1
Aug 27 2018 · Understanding the Impact of Platelet ABO MatchingPart 1 The Basics. There has been an ongoing debate over the importance of ABO matching for platelet transfusions for well over 50 years. A survey from 2007 showed that 17 of North American institutions did not have a formal ABO policy and 50 of the institutions with a policy gave ABO
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Platelet Refractoriness AACC
Nov 10 2015 · Welcome to this Pearl of Laboratory Medicine on "Platelet Refractoriness." Platelet transfusions are a common therapeutic intervention in patients who are bleeding or who are at risk for bleeding and are thrombocytopenic.
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Platelet Alloantibody Workup-BasicBloodworks Northwest
Platelet Alloantibody Workup-Basic. Also Known as (Alias) Platelet Refractory Antibody. Method. Flow Cytometry using beads coated with recombinant or soluble HLA antigens. Test Information. Multiply transfused patients may become alloimmunized to foreign donors. Patients who have failed to respond to two consecutive random donor platelet
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Platelet transfusion basic aspects
Platelet transfusions have been shown to prevent major haemorrhage and improve survival in thrombocytopenic patients. Since then advances in the preparation of platelet components including the introduction of pathogen reduction techniques have been achieved.
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Platelet transfusion refractorinessHod2008British
Platelet refractoriness can be simply defined as a post‐transfusion platelet increment that is less than expected. The difficulty in making this diagnosis arises in the specifics with a lack of agreement regarding the precise definition (Phekoo et al 1997).
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Systematic Use of Leukocyte‐Free Blood Components to
The basic diagnoses included acute leukemia pediatric solid tumors and severe aplastic anemia. We also present a reference group of 10 similarly multitransfused children who either deliberately or inadvertently had received nonfiltered blood products on some occasions. In the study group of 50 children none developed platelet refractoriness.
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Platelets for the Refractory Climbing the Pyramid Eric Senaldi MD Medical Director NYBC Objectives 1. Discuss the pathophysiology and prevention of platelet refractoriness. 2. Describe methods to select appropriate products for platelet refractoriness. 3. List options for when appropriate products don t provide adequate response.
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Platelet Alloantibody Workup-BasicBloodworks Northwest
Platelet Alloantibody Workup-Basic. Also Known as (Alias) Platelet Refractory Antibody. Method. Flow Cytometry using beads coated with recombinant or soluble HLA antigens. Test Information. Multiply transfused patients may become alloimmunized to foreign donors. Patients who have failed to respond to two consecutive random donor platelet
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CCI Platelet Refractoriness iheartpathology
Platelet refractoriness due to an immune-mediated response (antibodies against the platelets) is defined as a CCI less than 7500 (or 5000 according to some sources) on
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Platelet Transfusion Practices in the ICUCHEST
Between April 2006 and September 2015 47 076 nononcology patients were admitted to the ICUs at three hospitals. Of these patients 7 073 (15.0 ) received 15 879 platelet transfusions ( Fig 1 ) 31.1 of transfused patients were women with a median age of 69 years at the time of first ICU admission. Of all admissions during which platelet
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Platelet Alloantibody Workup-BasicBloodworks Northwest
Platelet Alloantibody Workup-Basic. Also Known as (Alias) Platelet Refractory Antibody. Method. Flow Cytometry using beads coated with recombinant or soluble HLA antigens. Test Information. Multiply transfused patients may become alloimmunized to foreign donors. Patients who have failed to respond to two consecutive random donor platelet
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Transfusion in haemato-oncology
8.7.4 Refractoriness to platelet transfusion Refractoriness is the repeated failure to obtain a satisfactory response to platelet transfusion. Control of bleeding is the most clinically relevant marker but in practice it is usual to measure the increase in platelet count after transfusion.
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Platelet refractoriness Request PDF
Platelet refractoriness (unsatisfactory post-transfusion platelet increment) is a severe problem that impairs the treatment of oncohematologic patients and is not routinely investigated in most
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Addressing Platelet Refractoriness Giving Hematology
Jan 24 2018 · The activation of platelets is a well-documented phenomenon. It is now clear that many donated platelet transfusions contain activated platelets. This situation can lead to serious implications for the treatment of hematology-oncology patients who are dependent on platelet transfusion support during their treatment. This webinar will introduce activated platelets and their prevalence discuss
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The Basics of Platelet Transfusion
• Platelet Basics • Platelet refractoriness is a persistent lack of post-transfusion platelet count increment Platelet Refractoriness Immune factors (<20 ) Alloimmune to HLA Class I (80-90 ) Alloimmune to HPA (10-20 ) Other allo or
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HLA- and HPA-Alloimmunization Rate In the Setting of
Nov 18 2011 · At our institution platelet refractoriness is defined as a platelet count rise of <10 10 9 /L measured within 24 hours post-transfusion of ABO-matched single-donor platelets on at least two occasions. In this circumstance HLA matched platelets have been provided regardless of the HLA/HPA alloimmunization status.
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PPT Basics of Transfusion TherapyMichigan Medicine
Platelet Refractoriness Laura Cooling MD MS Associate Medical Director Transfusion Medicine Platelet Kinetics circulating life span 8-10 days Definitions of Refractoriness 2-3 consecutive platelet transfusions by CCI or PPR REFRACTORINESS ALLOIMMUNIZATION Platelet Refractoriness Immune (25-50 ) Alloimmunization Autoantibodies Passive Immunity Drug-related Nonimmune (50
Get PriceDoes Platelet-Rich Plasma Deserve a Role in the Treatment
Platelet-rich plasma (PRP) which contains a host of soluble mediators including growth factors has been suggested as a second-line treatment for refractory tendinopathy with the goal of expediting tendon healing or remodeling. Here we report a systematic literature review of basic research data from humans and animals that support the
Get PricePlatelet Transfusion TherapyNational Institutes of Health
More basic research to elucidate the role of platelets in hemostasis is needed. In addition better information on current platelet transfusion practices obtained through a surveillance system at a national level would be of great benefit as an educational tool. "Refractoriness to Platelet Transfusions" Associate Professor of Medicine and
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May 01 2020 · Platelet refractoriness is defined as failure to achieve a satisfactory platelet count in a patient after two or more consecutive transfusions of allogeneic platelets.
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Understanding the Impact of Platelet ABO MatchingPart 1
Aug 27 2018 · Understanding the Impact of Platelet ABO MatchingPart 1 The Basics. There has been an ongoing debate over the importance of ABO matching for platelet transfusions for well over 50 years. A survey from 2007 showed that 17 of North American institutions did not have a formal ABO policy and 50 of the institutions with a policy gave ABO
Get Price
Webinar The HLA-As and Bs of Platelet Refractoriness
Mar 10 2021 · Anti-HLA antibodies are a frequent cause of refractoriness to platelet transfusions and as a result blood banks are often called on to provide HLA-matched or HLA-compatible platelets. We will discuss current testing methodologies and platelet selection strategies as well as newer approaches. Level Basic. Grace Mahowald MD PhD D(ABHI)
Get PricePlatelet refractorinesspractical approaches and ongoing
Platelet transfusion refractoriness is defined as the repeated failure to achieve satisfactory responses to platelet transfusions from random donors (Murphy 2014).
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