pediatric super refractory status epilepticus treated with
Treatment options in pediatric super-refractory status
Conclusion The majority of pediatric SRSE does not have epilepsy and the etiology is various. Treatment should expand from antiepileptic drugs to other modalities targeting different possible mechanisms such as immunomodulation or specific metabolic treatment. Multiple anesthetic drugs could be tolerated with close monitoring.
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PulmCrit- Resuscitationist s guide to status epilepticus
May 08 2017 · Ketamine is a powerful anti-epileptic agent. For example ketamine has shown efficacy in status epilepticus refractory to a variety of other medications. Consequently some guidelines have added ketamine as a possible treatment for super-refractory status epilepticus (Fung 2017).
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Evidence-Based Guideline Treatment of Convulsive Status
treatment of refractory status epilepticus treatment of neo-natal status epilepticus subsequent chronic anticonvulsant therapy etiology-specific therapy (e.g. for cerebral malaria) the role of different diagnostic tests (e.g. EEG CT MRI) for patients with status epilepticus the role of epilepsy surgery
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A JOURNAL OF NEUROLOGY REVIEWARTICLE The treatment
Aims of treatment in super-refractory status epilepticus The primary aim of treatment in the earlier phases of status epi-lepticus is to control seizures with the objective of preventing ini-tial excitotoxicity. In super-refractory status epilepticus this also remains an objective but it
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UpToDate
The ketogenic diet as broad-spectrum treatment for super-refractory pediatric status epilepticus challenges in implementation in the pediatric and neonatal intensive care units. J Child Neurol 2015 30 259. O Connor SE Ream MA Richardson C et al. The ketogenic diet for the treatment of pediatric status epilepticus. Pediatr Neurol 2014 50 101.
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Treatment options in pediatric super-refractory status
Super-refractory status epilepticus (SRSE) is a seizure that continues >24 h after anesthesia or recurs on the reduction of anesthesia. SRSE is extremely difficult-to-control and associated with poor outcome. To date optimal therapy and outcome data in children is limited.
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New-onset refractory status epilepticus Genetic and Rare
Dec 29 2020 · The cause of status epilepticus (SE) can be found during initial tests in about 80 of cases. The remaining cases are classified as new-onset refractory status epilepticus (NORSE). Further more extensive testing finds a cause in about 40 of NORSE cases including autoimmune encephalitis paraneoplastic encephalitis other known inflammatory or autoimmune diseases rare
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UNM Neonatal Pediatric Status Epilepticus Pathway
UNM Pediatric Status EpilepticusPathway Super refractory status epilepticustreatment options Notes • Max rate 3.5 mg/kg/h • Doses as high as 10 mg/kg/h have been used in adults Reference • IlventoL et al. Ketamine in refractory convulsive status epilepticus in children avoids endotracheal intubation Epilepsy and Behavior(2015)
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Pediatric super-refractory status epilepticus treated with
Abstract Super-refractory status epilepticus is a life-threatening condition. Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be due to internalization of synaptic γ-aminobutyric acid (GABA)A receptors and withdrawal of benzodiazepines and barbiturates during treatment often triggers seizure recurrence.
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UNM Neonatal Pediatric Status Epilepticus Pathway
UNM Pediatric Status EpilepticusPathway Super refractory status epilepticustreatment options Notes • Max rate 3.5 mg/kg/h • Doses as high as 10 mg/kg/h have been used in adults Reference • IlventoL et al. Ketamine in refractory convulsive status epilepticus in children avoids endotracheal intubation Epilepsy and Behavior(2015)
Get Price(PDF) Super-refractory status epilepticus Treatment with
Super-refractory status epilepticus is that which persists despite suitable treatment with multiple anti-convulsive schemes including prolonged coma with general anaesthetic.
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Treatment of Refractory and Super-refractory Status
Jun 19 2018 · Refractory and super-refractory status epilepticus (SE) are serious illnesses with a high risk of morbidity and even fatality. In the setting of refractory generalized convulsive SE (GCSE) there is ample justification to use continuous infusions of highly sedating medications—usually midazolam pentobarbital or propofol. Each of these medications has advantages and disadvantages
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Pediatric refractory and super-refractory status epilepticus
Pediatric refractory and super-refractory status epilepticus RSE and SRSE are neurological emergencies with limited therapeutic options. Multi-national collaborative efforts are desirable to evaluate the safety and efficacy of current RSE/SRSE therapies and potentially impact patients outcomes.
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Treatment options in pediatric super-refractory status
Super-refractory status epilepticus (SRSE) is a seizure that continues >24 h after anesthesia or recurs on the reduction of anesthesia. SRSE is extremely difficult-to-control and associated with poor outcome. To date optimal therapy and outcome data in children is limited.
Get Price
UNM Neonatal Pediatric Status Epilepticus Pathway
UNM Pediatric Status EpilepticusPathway Super refractory status epilepticustreatment options Notes • Max rate 3.5 mg/kg/h • Doses as high as 10 mg/kg/h have been used in adults Reference • IlventoL et al. Ketamine in refractory convulsive status epilepticus in children avoids endotracheal intubation Epilepsy and Behavior(2015)
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Pediatric super‐refractory status epilepticus treated with
Oct 31 2014 · The neurosteroid allopregnanolone acts as a positive allosteric modulator of synaptic and extrasynaptic GABA A receptors. Here we describe the use of allopregnanolone in 2 pediatric patients with super‐refractory status epilepticus. This treatment allowed the general anesthetic infusions to be weaned with resolution of status epilepticus.
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Refractory and Super-refractory Status Epilepticus
Electroencephalography monitoring is essential to monitor treatment response in refractory/super-refractory status epilepticus and to diagnose non-convulsive status epilepticus. The mainstay of treatment for these disorders includes anesthetic infusions primarily midazolam ketamine and
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Treatment of Refractory and Super-refractory Status
Refractory and super-refractory status epilepticus (SE) are serious illnesses with a high risk of morbidity and even fatality. In the setting of refractory generalized convulsive SE (GCSE) there is ample justification to use continuous infusions of highly sedating medications-usually midazolam pentobarbital or propofol.
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Treatment of Super-Refractory Status Epilepticus A Review
Mar 10 2021 · Super-refractory status epilepticus (SRSE) is defined as seizure activity greater than 24 hours despite treatment with an anesthetizing ASM. 2 This includes cases in which seizures recur with an attempted withdrawal of the anesthetics. 3 4
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Treatment of Refractory and Super-refractory Status
Jun 19 2018 · Refractory and super-refractory status epilepticus (SE) are serious illnesses with a high risk of morbidity and even fatality. In the setting of refractory generalized convulsive SE (GCSE) there is ample justification to use continuous infusions of highly sedating medications—usually midazolam pentobarbital or propofol. Each of these medications has advantages and disadvantages
Get Price
Pediatric Super-Refractory Status Epilepticus Treated with
The neurosteroid allopregnanolone acts as a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors. Here we describe the use of allopregnanolone in two pediatric patients with
Get PriceUpToDate
The ketogenic diet as broad-spectrum treatment for super-refractory pediatric status epilepticus challenges in implementation in the pediatric and neonatal intensive care units. J Child Neurol 2015 30 259. O Connor SE Ream MA Richardson C et al. The ketogenic diet for the treatment of pediatric status epilepticus. Pediatr Neurol 2014 50 101.
Get Price
Ketogenic Diet Initiation Management for Refractory
Mar 06 2017 · "The treatment of super-refractory status epilepticus a critical review of available therapies and a clinical treatment protocol." Brain 2011 134 . Sort R Born AP et al. Ketogenic diet in 3 cases of childhood refractory status epilepticus. European Paediatric Neurology Society 2013
Get PriceEfficacy of ketamine in refractory convulsive status
Introduction Status epilepticus (SE) is a life-threatening neurological emergency. SE lasting longer than 120 min and not responding to first-line and second-line antiepileptic drugs is defined as refractory (RCSE) and requires intensive care unit treatment. There is currently neither evidence nor consensus to guide either the optimal choice of therapy or treatment goals for RCSE which
Get PriceBrexanolone as adjunctive therapy in super‐refractory
Super‐refractory status epilepticus (SRSE) is a life‐threatening form of status epilepticus that continues or recurs despite 24 hours or more of anesthetic treatment. We conducted a multicenter phase 1/2 study in SRSE patients to evaluate the safety and tolerability of brexanolone (USAN formerly SAGE‐547 Injection) a proprietary
Get PriceEfficacy of ketamine in refractory convulsive status
Introduction Status epilepticus (SE) is a life-threatening neurological emergency. SE lasting longer than 120 min and not responding to first-line and second-line antiepileptic drugs is defined as refractory (RCSE) and requires intensive care unit treatment. There is currently neither evidence nor consensus to guide either the optimal choice of therapy or treatment goals for RCSE which
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New-onset refractory status epilepticus (NORSE
Vagus nerve stimulation is increasingly used for refractory and super-refractory status epilepticus 80 81 including one patient with NORSE. 81 The stimulator was implanted on day 5 in a 25-year-old man with cessation of status for 72 hours. Seizures recurred thereafter and
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Ketamine for the treatment of refractory status epilepticus
Aug 01 2015 · Refractory status epilepticus (RSE) refers to status epilepticus (SE) that cannot be resolved in terms of clinical manifestations or epileptiform discharges following the rational administration of anticonvulsants including a benzodiazepine.
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Refractory and Super-refractory Status Epilepticus
Context Refractory status epilepticus (RSE) and super-refractory status epilepticus (SRSE) are neurological emergencies with considerable mortality and morbidity. In this paper we provide an overview of causes evaluation treatment and consequences of RSE and SRSE reflecting the lack of high-quality evidence to inform therapeutic approach.
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